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Physics of biological tissues

mayo 28 / 4:15 pm - 5:30 pm

Jean-François Joanny
Collège de France París

This seminar gives a review of our work on biological tissues which focuses on the interplay between tissue growth due to cell division and cell death and its mechanical properties. The theoretical description of tissues can be made at two levels. At the microscopic scale of the cells, tissues are well described by vertex models in analogy with foams in two or three dimensions. At the more macroscopic level, we use a continuum mechanics description coupled to tissue growth. We give two examples. Multicellular spheroids are spherical aggregates of cancerous cells which are used to study the effect of drugs. They behave as liquids with a very large viscosity. We show the example of spheroids made of two cell types, cancer cells and macrophages, which undergo a spinodal instability during growth. Human pluripotent stem cells form hollow spheres called cysts. The cysts can be considered as solid spherical shells. The magnitude of the elastic stresses generated during growth seems to play an important role in the differentiation of the stem cells. Finally, we give the example of nematic cell layers that must be described as active nematic liquids.


El seminario será transmitido via Zoom por el enlace

Meeting ID: 849 6454 6506
Passcode: 843734

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mayo 28
4:15 pm - 5:30 pm
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